Nanoparticle drug delivery for hard-to-deliver molecules
NaDeNo’s nanoparticle drug delivery technology enables targeted delivery for hard-to-deliver molecules. Our proprietary manufacturing process encapsulates molecules in a simple 1-step without any chemical modification.
The platform allows controlled release, a range of administration routes, surface functionalisation, and adaptation of targeting and retention properties across molecule classes and indications.
Many potent molecules fail because they cannot be delivered effectively
The problem
Traditional drug delivery utilizes systemic delivery with low or no specificity, meaning target cells are not reached due to biological barriers, and a majority of promising drugs don’t translate to effect in humans.
Barriers include poor solubility, hydrophobicity, low target-site exposure, rapid clearance, systemic toxicity, all leading to formulation limitations.
Our solution
NaDeNo’s nanoparticle drug delivery platform enables delivery of hard-to-deliver molecules without chemical modification. It is a versatile platform applicable for a variety of molecular classes and indications.
This creates opportunities to improve existing molecules, revive formulation-limited candidates and support differentiated new therapeutics.
NaDeNo’s platform enables novel therapeutics, and we are open to co-developments with companies in need of a drug delivery technology
Drug compatibility
NaDeNo’s platform is designed for hydrophobic and hard-to-deliver molecules where conventional formulation or systemic delivery limits therapeutic potential. The technology has been explored across molecule classes, indications and routes of administration.
Sustainable & scalable manufacturing
Our proprietary one-step manufacturing process encapsulates molecules in polymeric nanoparticles without chemical modification. This enables formulation of potent molecules while preserving their original mode of action.
Adaptive targeting
The nanoparticle surface can be adapted to influence targeting, biodistribution, and tissue interaction. This creates opportunities for chemical or biological targeting and for tailoring the platform to specific therapeutic applications.
Retention and controlled release
NaDeNo’s nanoparticles are designed to support local retention and controlled drug release, enabling sustained exposure at the target site. This may improve therapeutic effect while reducing unnecessary systemic exposure.