Nanoparticle drug delivery for hard-to-deliver molecules
NaDeNo’s nanoparticle drug delivery technology enables targeted delivery for hard-to-deliver molecules. Our manufacturing process enables drug encapsulation through a proprietary one-step process without the need for chemical modification or organic solvents.
The platform allows controlled release, a range of administration routes, surface functionalisation, and adaptation of targeting and retention properties across molecule classes and indications.
NaDeNo is interested in collaborations involving poorly soluble molecules that may benefit from improved formulation, local retention, controlled release or nanoparticle-enabled delivery. Potential partners are invited to contact us for an initial non-confidential discussion.
Many potent molecules fail because they cannot be delivered effectively
The problem
Traditional drug delivery utilizes systemic delivery with low or no specificity, meaning target cells are not reached due to biological barriers, and a majority of promising drugs don’t translate to effect in humans.
Barriers include poor solubility, hydrophobicity, low target-site exposure, rapid clearance, systemic toxicity, all leading to formulation limitations.
Our solution
NaDeNo’s nanoparticle drug delivery platform enables delivery of hard-to-deliver molecules without chemical modification. It is a versatile platform applicable to a variety of molecular classes and indications.
This creates opportunities to improve existing molecules, revive formulation-limited candidates and support differentiated new therapeutics.
NaDeNo’s platform enables novel therapeutics, and we are seeking co-developments with companies in need of a drug delivery technology
Drug compatibility
NaDeNo’s platform is designed for hydrophobic and hard-to-deliver molecules where conventional formulation or systemic delivery limits therapeutic potential. The platform can be applied to a range of molecular classes, indications, and routes of administration.
Sustainable & scalable manufacturing
Our proprietary one-step manufacturing process encapsulates molecules in polymeric nanoparticles without chemical modification. This enables formulation of potent molecules while preserving their original mode of action.
Adaptive targeting
The nanoparticle surface can be adapted to influence targeting, biodistribution, and tissue interaction. This creates opportunities for chemical or biological targeting and for tailoring the platform to specific therapeutic applications.
Retention and controlled release
NaDeNo’s nanoparticles are designed to support local retention and controlled drug release, enabling sustained exposure at the target site. This may improve therapeutic effect while reducing unnecessary systemic exposure.